Ferrostatin-1 (Fer-1, #S7243), haloperidol (#S1920), deferoxamine mesylate (DFO, #S5742), temozolomide (#S1237), necrostatin-1 (Nec-1, #S8037), Z-VAD(OH)-FMK (#S8102), RSL3 (#S8155), N-Nitro-L-nitroarginine methyl ester (L-NAME, #S2877), N-acetylcysteine (NAC, #S1623), Indomethacin (INDO, #S1723), 3-methyladenine (3-MA, #S2767), and bafilomycin A1 (Baf-A1, # S1413) were purchased from Selleck Chemicals (Houston, Texas). Antibodies specific for MGMT (AB_2800069), LC3 I/II (AB_2617131), GRP78 (AB_2119845), p-PERK (AB_2095853), PERK (AB_10841299), ATF-4 (AB_2616025), phosphorylated protein kinase A (p-PKA, AB_330304), and FTH1 (AB_11217441) were purchased from Cell Signaling Technology (Massachusetts). Antibodies specific for DRD2 (AB_2759776), NCOA4 (AB_2766454) and GAPDH (AB_2619673) were purchased from ABclonal Technology Co., Ltd. (Wuhan, China). Antibodies specific for 4-HNE (AB_867452) were purchased from Abcam (Cambridge, United Kingdom).